Response to Infectious Disease (ID) and Antimicrobial Resistance (AMR) detection includes prevention and control measures, which typically occur within specific public health or agriculture departments, and involve community engagement where many barriers to effective governance are located. The magnitude and nature of the response measures depend upon the urgency of the situation, such as an acute event (outbreak) or an endemic situation, and its frequency and severity for different species or populations. An important challenge in responding to an ID event is the coordination and active collaboration required between various agencies for a unified, timely response, both in local communities and for global efforts to prevent pandemic transmission of IDs. This challenge can arise from a lack of mechanisms for inter-agency collaboration and an absence of operational support for a coordinated response applying One Health principles. To overcome such obstacles at different governance scales, a core group of motivated individuals with strong institutional support is needed to begin the process of fostering a commitment for sustainable coordination and collaboration. We will initiate transdisciplinary literature reviews using an equity lens to identify specific barriers and enablers to the implementation of global OH interventions to prevent or control IDs and AMR.